• In used WGS to investigate

  2018-10-23

  

  In , used WGS to investigate a 40-year meningococcal disease pandemic caused by the hyperinvasive ET-5/ST-32 complex. A global collection of forty-three isolates, including 14 different MLST STs, cultured from 1969 to 2008 was investigated, to set a baseline for the hyperinvasive ET-5/ST-32 complex.

• Age influenced the results significantly only for DT

  2018-10-23

  

  Age influenced the results significantly only for DT (effect −0. 0255ms [−0·0443, −0·0067] per annum, p=0·0122). In the analysis on the extended dataset the age effect on DT disappeared, whereas a significant age effect was detected on E′ (effect −0·0021m/s [−0·0036, −0·007] per annum, p=0·0051). Ho

• br Main Trial br Authors

  2018-10-23

  

  Main Trial Authors\' Contributions Role of Funding Source National Institute for Health Research Health Technology Assessment (NIHR HTA) (09/55/52) Programme provided funding for the trial, and monitored and advised on the trial\'s progress. The trial is also supported by service support co

• We conducted a population based GWAS of

  2018-10-23

  

  We conducted a population-based GWAS of diabetic neuropathic pain in which our case definition was matched with previous population-based observational studies of diabetic neuropathic pain (Hall et al., 2013; Dieleman et al., 2008), seeking candidate Senexin A that might not have been identified us

• Anemia is common in diabetes with multiple causes

  2018-10-23

  

  Anemia is common in diabetes, with multiple causes (Thomas et al., 2003, 2006; Craig et al., 2005). Low RBC ascorbate might contribute to anemia, possibly via low grade chronic hemolysis produced by RBC rigidity. Future studies of diabetic subjects will include measurement of cell-free hemoglobin an

• br Methods br Results The

  2018-10-23

  

  Methods Results The mean (standard error) LTL of the study p2y inhibitor (n=2431) was 1.06 (0.02). The weighted distributions of study population characteristics of the total sample are shown in Table 1). Women represented slightly over 51% of the total sample; the geometric mean age of the p

• A pharmacometabolomics aided pharmacogenomics workflow

  2018-10-23

  

  A “pharmacometabolomics-aided pharmacogenomics” workflow includes sample acquisition and preparation, analysis (NMR or mass spectrometry technologies), data processing and data analysis (targeted and non-targeted) (Mussap et al., 2013). For those familiar with (pharmaco)metabolomics approaches, such

• We may be on the cusp of

  2018-10-23

  

  We may be on the cusp of potential breakthroughs in lipid-targeted treatment of AMD. Genome wide association studies (GWAS) of AMD patients have demonstrated polymorphisms in multiple genes involved in cholesterol homeostasis (). Some examples are ATP-binding cassette transporter member 1 (ABCA1), w

• fda approved Increasing globalization in travel and trade

  2018-10-23

  

  Increasing globalization in travel and trade will intensify the importation of dengue viruses and the potential for further introduction of Ae. aegypti (Gubler and Clark, 1995). If such introductions coincide with suitable vectorial capacity, those cities at the time intervals identified in this stu

• Health care information technology is advancing rapidly crea

  2018-10-23

  

  Health-care information technology is advancing rapidly, creating new opportunities for the accurate reconstruction of comprehensive drug-exposure histories of individuals. Here, have used this approach to address their Histone Compound Library that pharmaceutical agents may possess long-term carc

• dexamethasone acetate Conversely ECM accumulation in the liv

  2018-10-23

  

  Conversely, ECM accumulation in the liver is a hallmark of hepatic fibrosis and is associated with hepatic stellate cell activation due to inflammatory signaling (Bataller and Brenner, 2005). ECM reprogramming is necessary for adipose growth and expansion on energy dense diets, and fibrosis in fat t

• Progress toward the treatment of three

  2018-10-23

  

  Progress toward the treatment of three major parasitic diseases (sleeping sickness, Chagas disease, and leishmaniasis) was recently demonstrated in an article published online last month in the journal (August 8, 2016). Collectively, these three diseases affect 20 million people per year, resulting

• Glycoproteins have an important role in

  2018-10-23

  

  Glycoproteins have an important role in inflammation, and their synthesis and secretion increases during inflammatory processes (Connelly et al., 2016). We observed that the levels of circulating glycoproteins were higher in patients with pneumonia than in those without. Patients who developed VAP h

• Here we show that the genetic disruption of

  2018-10-23

  

  Here, we show that the genetic disruption of the regulatory system maintaining systemic iron homeostasis causes age-dependent and genotype-specific pulmonary iron accumulation, increased lipid peroxidation, and gene responses consistent with pulmonary iron overload and oxidative stress; TfR1 and DMT

• mitotic inhibitor br Funding This work was funded by the Nat

  2018-10-23

  

  Funding This work was funded by the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID) contract HHSN272200800047C to EP. The Kawempe Community Health Study was funded entirely by the Tuberculosis Research Unit (grant N01-AI95383 and HHSN266200700022C

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