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Vacuolar ATPases V ATPases are large multi
2018-11-12
Vacuolar ATPases (V-ATPases) are large multi-subunit complexes that are organized into V0 and V1 domains, which operate by a rotary mechanism (Forgac, 2007). V-ATPase-driven proton pumping and organellar acidification are essential for vesicular trafficking along both the exocytotic and endocytotic
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Introduction The mechanisms by which pluripotency regulators
2018-11-12
Introduction The mechanisms by which pluripotency regulators dictate self-renewal versus differentiation are only recently being studied (Wagner et al., 2010; Niwa et al., 2009). In addition, various approaches are being developed to examine such processes (Wang et al, 2013). The transcriptional re
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Human fibroblasts were reprogrammed from
2018-11-12
Human fibroblasts were reprogrammed from an individual into nociceptor neurons without creation of iPSCs and the neurons exhibited sensitization to the chemotherapeutic drug oxaliplatin, modeling the inherent mechanisms underlying painful CIPN (Wainger et al., 2015); however, the advantage to creati
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Reduction of heterogeneity during reprogramming is critical
2018-11-09
Reduction of heterogeneity during reprogramming is critical for revealing molecular roadmaps and precise mechanistic analysis. In this regard, the use of 2A peptides constituted a significant improvement (Carey et al., 2009; Kaji et al., 2009; Okita et al., 2008; Sommer et al., 2009; Yusa et al., 20
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EnvA SAD G mCherry rabies virus was injected
2018-11-09
EnvA-SADΔG-mCherry rabies virus was injected 1–3 months after injury/grafts into a total of eight sites in Rabies-Helper grafts (n = 8 animals). Animals were killed 1 week later. Only graft-derived neurons from Rabies-Helper grafts should be capable of being primarily infected by the pseudotyped rab
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Expansion is a canonical white noise expansion
2018-11-09
Expansion is a canonical white-noise expansion in terms of a wavelet basis, i.e., it is a sum of random quantities multiplied by determinate time-varying functions, in this case, wavelet ones. Amiantov\'s study proved, in particular, the assumption that the probability density functional takes th
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Using the Cox regression model
2018-11-09
Using the Cox regression model, 30 GOI with the new reference distribution of gene-expression levels, it was possible to distinguish mastectomy patients into the LRR low/high risk groups for the data set published in 2006 (Table 2) (Cheng et al., 2006b). This 30-gene panel could also distinguish the
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The recent Zika virus ZIKV
2018-11-09
The recent Zika virus (ZIKV) outbreak has been declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization in February 2016. It started in Brazil in 2015, rapidly spread through South and Central America, and is expected to reach the continental US in the sum
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br Materials and Methods DEFI is a French
2018-11-09
Materials and Methods DEFI is a French national study set up in 2004 to collect clinical data and biological specimens from adult patients with primary hypogammaglobulinaemia (Oksenhendler et al., 2008). The inclusion criteria in the DEFI study were adult patients with primary hypogammaglobulinae
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In this issue of EBioMedicine Enroth and
2018-11-09
In this issue of EBioMedicine, Enroth and colleagues () present a comprehensive study that analyzes the individual contribution of factors related to the collection and long-term sample storage in a highly homogenous group of Northern European subjects (). Taking advantage of the sampling strategy o
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The succesful development of flavivirus vaccines began years
2018-11-09
The succesful development of flavivirus vaccines began 80years ago in 1937 with the yellow fever YFV17D live-attenuated vaccine (Monath, 2008). Since then, >600 million people have been vaccinated, with 98% protection and a >10year persistence of vaccine–induced immunity (Barrett and Teuwen, 2009).
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The results from the variable selection are presented in
2018-11-09
The results from the variable selection are presented in Table 2. These results compare well with the importance ranking of variables in the random forest and bagging procedures. Similarly, to the previous results, we can see that orexin antagonist the current income, income 2005 and 2002 and other
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The traditional econometric approach of linking fuel
2018-11-09
The traditional econometric approach of linking fuel usage to factors that could influence it employs economic theory to derive a model for statistical regression. However, econometric approach may fail to capture all factors that influence rural household\'s choices in regards to cooking fuel. Alth
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Anti-diabetic Compound Library In order to analyze and illus
2018-11-09
In order to analyze and illustrate (Table 1, Figs. 2–3) steepness of changes in the EEG indexes during transitions from one stage to another, one-min values were further averaged on 3-min intervals (i.e., from minute −4 to −2, from −1 to +1, from +2 to +4, etc.). Additionally, all positive and negat
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OAs can be divided into
2018-11-09
OAs can be divided into two groups: mandibular advancement devices (MADs), which are attached to the teeth and move the mandible anteriorly, and tongue retaining devices, which use suction to position the tongue anteriorly inside a bulb [5]. MADs have higher success and compliance rates than tongue
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