• Analgesia is an important ancillary

  2018-11-06

  

  Analgesia is an important ancillary property of all anti-inflammatory agents. Most of the anti-inflammatory drugs increased pain threshold in various animal models [44]. This is natural because many endogenous chemical mediators of inflammation play a part in generating pain impulses (for example, h

• br Acknowledgements br Introduction Major

  2018-11-06

  

  Acknowledgements Introduction Major research interests have been attributed to reactive oxygen species (ROS) and their likely involvement in human physiopathology from the health point over the last few decades. Oxidative stress, caused by an imbalance between antioxidant systems and the produ

• br Concluding remarks Overall the achievements

  2018-11-06

  

  Concluding remarks Overall, the achievements in food toxicology in the last decades have been significant gaining a deeper understanding of the molecular mode of action by which toxic effects are induced. These mechanistic insights have helped to identify potential toxicants thus enhancing food s

• br Introduction Currently heart disease

  2018-11-06

  

  Introduction Currently, heart disease is the leading cause of mortality in the industrialized world, partly due to the inability of the heart to regenerate in adults; and also the dietary and life style changes leading to a marked increase in the incidence of type II diabetes (for review, see Arm

• br Cardiomyocyte cycling increases after myocardial injury b

  2018-11-06

  

  Cardiomyocyte cycling increases after myocardial injury, but does not lead to effective regeneration In adult mice after experimental myocardial infarction, the border zone shows a 10-fold increase of cardiomyocyte liquiritin activity. As described above, the α-MHC-MerCreMer mouse in combination

• 10058-F4 In our prior studies we showed that K RasG D

  2018-11-06

  

  In our prior studies, we showed that K-RasG12D promotes proliferation in the intestinal epithelium by activating MEK, but that K-RasG12D promotes proliferation of colorectal cancer 10058-F4 through a MEK-independent mechanism (Haigis et al., 2008). To determine whether K-RasG12D promotes quiescent s

• Osteoarthritis OA is a common joint disease associated with

  2018-11-06

  

  Osteoarthritis (OA) is a common joint disease associated with articular cartilage degeneration. To improve the therapeutic options of OA, tissue engineering based on the use of hBMSCs has become prominent; however, the presence of inflammatory cytokines, such as interleukin-1β (IL-1β), during the c

• Progression of maladaptive LV remodeling increased wall stre

  2018-11-06

  

  Progression of maladaptive LV remodeling, increased wall stress and transition to heart failure are associated with an enhanced cardiac production of natriuretic peptides (Hohl et al. 2013; van Veldhuisen et al. 2013). TAC led to a marked five- to twenty-fold increase of myocardial BNP and ANP expre

• br Materials and methods br Acknowledgements We would

  2018-11-06

  

  Materials and methods Acknowledgements We would like to thank Dr. Mahito Nakanishi, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, for providing SeVdp. We would also like to thank the following financial supports; JSPS KAKENHI Grant

• br Methods br Results br Discussion Our method for osteoprog

  2018-11-06

  

  Methods Results Discussion Our method for osteoprogenitor cell culture is similar to protocols for mice (Meirelles and Nardi, 2003; Soleimani and Nadri, 2009; Nardi and Camassola, 2011; Abdelmagid et al., 2014; Fig. 1). Marrow and cortex-derived cell populations of bats and mice shared simi

• br Materials and methods br Results br

  2018-11-06

  

  Materials and methods Results Discussion The role played by Nurr1 in the regulation of NPCs across several A-443654 regions has been extensively investigated. It has been suggested that Nurr1 may exert a strong control on both the proliferation and differentiation of NPCs into neurons. Thes

• br Summary The newly developed

  2018-11-05

  

  Summary The newly developed analyzer Soffron60 is designed for operation with GESA electron-beam material-treatment facilities [1] and can be used at machines with similar characteristics (∼60 kV, ∼100 A, ∼100 µs, 0.1 T) or even with more energetic beam. The analyzer allows determination of tachy

• For example some optogenetic experiments require injecting v

  2018-11-05

  

  For example, some optogenetic experiments require injecting viral material to form photosensitive proteins in target cells and subsequent illumination through the tip of the optical fiber. Doing this as a two-stage process with two different implantable devices may compromise the accuracy of the exp

• If we consider the absorption of solar radiation without the

  2018-11-05

  

  If we consider the RHC 80267 of solar radiation without the ‘greenhouse glass’ in the range of emission frequencies of the Earth\'s surface, as well as in the frequency band of solar radiation adjacent to it, up to 3000cm (prior to our examination of the problem, it was a boundary above which the

• We had the opportunity to conduct a quantitative study of

  2018-11-05

  

  We had the opportunity to conduct a quantitative study of the spiritual health of adolescents through our involvement in the cross-national Health Behaviour in School-aged Children study, or HBSC (Freeman et al., 2011). This longstanding study involves researchers in some 43 countries or regions and

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