• Seaweeds contain a variety of potentially bioactive

  2018-11-12

  

  Seaweeds contain a variety of potentially bioactive compounds some of which are not present in terrestrial plants. These compounds include, for example, proteins such as lectins or phycobiliproteins, carotenoids, pigments, polyphenols, phlorotannins and certain polysaccharides. They may have health-

• The cell interactions to laminins as

  2018-11-12

  

  The cell interactions to laminins as well as other ECM proteins are mediated mainly through integrins, heterodimeric cell membrane receptors of one α (1–18) and one ß (1–8) subunit (Hynes, 2002). Human ESCs synthesize several integrin subunits: at least α3, α5, α6, α7, αV, ß1, ß5 and interaction wit

• Our survey of the effects

  2018-11-12

  

  Our survey of the effects of radiation, hypoxia, and gemcitabine on the SP shows that there may not be a consistent effect on this sub-population. This suggests that the SP alone may not be the best method to isolate pancreatic cancer stem cells. Other studies have found that CD24 and ALDH are enric

• Last but not least the differentiation method described

  2018-11-12

  

  Last, but not least, the differentiation method described here can be refined to be fully defined and xeno-free by substituting human serum albumin (HSA) present in RegES− medium with recombinant HSA (He et al., 2011) and using a higher certificate, xeno-free version of CnT-30 medium (CELLnTEC Advan

• Vacuolar ATPases V ATPases are large multi

  2018-11-12

  

  Vacuolar ATPases (V-ATPases) are large multi-subunit complexes that are organized into V0 and V1 domains, which operate by a rotary mechanism (Forgac, 2007). V-ATPase-driven proton pumping and organellar acidification are essential for vesicular trafficking along both the exocytotic and endocytotic

• Introduction The mechanisms by which pluripotency regulators

  2018-11-12

  

  Introduction The mechanisms by which pluripotency regulators dictate self-renewal versus differentiation are only recently being studied (Wagner et al., 2010; Niwa et al., 2009). In addition, various approaches are being developed to examine such processes (Wang et al, 2013). The transcriptional re

• Human fibroblasts were reprogrammed from

  2018-11-12

  

  Human fibroblasts were reprogrammed from an individual into nociceptor neurons without creation of iPSCs and the neurons exhibited sensitization to the chemotherapeutic drug oxaliplatin, modeling the inherent mechanisms underlying painful CIPN (Wainger et al., 2015); however, the advantage to creati

• Reduction of heterogeneity during reprogramming is critical

  2018-11-09

  

  Reduction of heterogeneity during reprogramming is critical for revealing molecular roadmaps and precise mechanistic analysis. In this regard, the use of 2A peptides constituted a significant improvement (Carey et al., 2009; Kaji et al., 2009; Okita et al., 2008; Sommer et al., 2009; Yusa et al., 20

• EnvA SAD G mCherry rabies virus was injected

  2018-11-09

  

  EnvA-SADΔG-mCherry rabies virus was injected 1–3 months after injury/grafts into a total of eight sites in Rabies-Helper grafts (n = 8 animals). Animals were killed 1 week later. Only graft-derived neurons from Rabies-Helper grafts should be capable of being primarily infected by the pseudotyped rab

• Expansion is a canonical white noise expansion

  2018-11-09

  

  Expansion is a canonical white-noise expansion in terms of a wavelet basis, i.e., it is a sum of random quantities multiplied by determinate time-varying functions, in this case, wavelet ones. Amiantov\'s study proved, in particular, the assumption that the probability density functional takes th

• Using the Cox regression model

  2018-11-09

  

  Using the Cox regression model, 30 GOI with the new reference distribution of gene-expression levels, it was possible to distinguish mastectomy patients into the LRR low/high risk groups for the data set published in 2006 (Table 2) (Cheng et al., 2006b). This 30-gene panel could also distinguish the

• The recent Zika virus ZIKV

  2018-11-09

  

  The recent Zika virus (ZIKV) outbreak has been declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization in February 2016. It started in Brazil in 2015, rapidly spread through South and Central America, and is expected to reach the continental US in the sum

• br Materials and Methods DEFI is a French

  2018-11-09

  

  Materials and Methods DEFI is a French national study set up in 2004 to collect clinical data and biological specimens from adult patients with primary hypogammaglobulinaemia (Oksenhendler et al., 2008). The inclusion criteria in the DEFI study were adult patients with primary hypogammaglobulinae

• In this issue of EBioMedicine Enroth and

  2018-11-09

  

  In this issue of EBioMedicine, Enroth and colleagues () present a comprehensive study that analyzes the individual contribution of factors related to the collection and long-term sample storage in a highly homogenous group of Northern European subjects (). Taking advantage of the sampling strategy o

• The succesful development of flavivirus vaccines began years

  2018-11-09

  

  The succesful development of flavivirus vaccines began 80years ago in 1937 with the yellow fever YFV17D live-attenuated vaccine (Monath, 2008). Since then, >600 million people have been vaccinated, with 98% protection and a >10year persistence of vaccine–induced immunity (Barrett and Teuwen, 2009).

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