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Introduction We have recently identified that caseinkinase
2020-07-28
Introduction We have recently identified that caseinkinase 2 (CK2) inhibition protects white matter (WM) from ischemic injury. We focused our research on CK2 because upregulation of CK2 activity is associated with many diseases, including ischemic injury [1,[6], [7], [8]]. This review highlights a
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In this study CK C prepared from BL DE
2020-07-28
In this study, CK1δ(ΔC) prepared from BL21(DE3)pλPP had the highest kinase activity among the three isoforms tested when using casein as a substrate. Therefore, CK1δ(ΔC) from BL21(DE3)pλPP has the potential to be a “phosphorylating reagent” that may be widely used in experiments of phosphorylation a
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Our results signify that both membrane anchored and soluble
2020-07-27
Our results signify that both membrane-anchored and soluble isoforms of DDR ECD sirtuins may be important in ECM remodeling. In this regard, several soluble collagen-binding proteins secreted in the ECM—decorin,3, 32, 33, 34 lumincan,3, 34, 35 biglycan,34, 36 fibromodulin,34, 35, 36 periostin, aggre
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B Hits with contact footprints similar to the known
2020-07-27
(B) Hits with contact footprints similar to the known inhibitors or true active compounds have greater chances to turn into competitive inhibitors. So in pose-clustering, interaction profiles of docking poses were compared with six well known antifolates (PYR, CYC, WR99210, TMP, MTX, INH1 and INH2)
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DDR receptor effector mechanisms are not
2020-07-27
DDR receptor effector mechanisms are not well understood. Most descriptions of DDR function have focused on downstream signaling pathways activated by collagen that regulate cell proliferation and transcriptional activation [7]. Natural occurring or induced DDR2−/− genotypes in mice induce dwarfism,
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br Role of DDR receptor in the development of Bone
2020-07-27
Role of DDR2 receptor in the development of Bone in human DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix
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Collectively the results presented here provide new insights
2020-07-27
Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of
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br Materials and methods br
2020-07-27
Materials and methods Results Discussion Although no increase in DAPK activity was detected at early time points associated with neuronal apoptosis, it is possible that the spread of apoptosis through the hmg-coa reductase inhibitor following HI is not synchronized enough to yield a large,
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Because bronchoconstriction is one of the causes of air trap
2020-07-27
Because bronchoconstriction is one of the causes of air-trapping, we comparatively evaluated the effect of an adrenergic β2 NSC 87877 agonist on LTC4- and LTD4-induced asthmatic responses in guinea pigs. Inhaled LTC4-induced increase in sRaw and airway hyperinflation in S-hexyl GSH-treated guinea p
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Effect modification of CYP A genotype on the association
2020-07-27
Effect modification of CYP3A genotype on the association between prenatal exposure to MeHg and child neurodevelopment was evaluated. For CYP3A7, the overall coefficient of cord blood THg on MDI was positive (i.e. improving MDI score with increasing cord blood THg concentrations) and statistically si
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The central role of TNF in inflammation
2020-07-27
The central role of TNF-α in inflammation and the immune system is established (reviewed in Ref. [34]) where it regulates such cellular processes as cytokine induction, proliferation, differentiation, and apoptosis. In contrast to these roles, however, several studies have suggested a function for T
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Expression of CSF R is normally
2020-07-27
Expression of CSF-1R is normally restricted to monocytes/macrophages, osteoclasts, and a few non-hematopoietic cell types including epithelial intestinal HU 308 of the colon and certain subpopulations of neurons [36]. In addition, CSF-1R is transiently expressed during processes that require tissue
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br Significance Preclinical data indicate that
2020-07-27
Significance Preclinical data indicate that tumor-associated macrophages (TAMs) represent an attractive therapeutic target as they represent key orchestrators of various tumor-promoting processes, such as escape of immune surveillance. Here, we report that treatment with an anti-CSF-1R antibody (
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Acknowledgements br Introduction Addiction is a life long co
2020-07-27
Acknowledgements Introduction Addiction is a life-long condition in which individuals show an intense drug craving and a high risk of relapse even after years of drug abstinence [1], [2]. A major goal of successful treatment of addiction is being able to prevent craving, seeking and relapse [3],
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br Thermodynamic modeling br Selection of data The
2020-07-27
Thermodynamic modeling Selection of data The solutes were selected based on the set of data needed to evaluate the CPA-EoS for prediction of their solubility in CO2 + cosolvent, as shown in Fig. 1. Critical temperatures, melting temperatures and enthalpies of fusion of the solutes are required
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