• Calmodulin CaM is a multifunctional

  2020-07-28

  

  Calmodulin (CaM) is a multifunctional calcium transducer [8]. It functions as a central regulator of cellular metabolism in response to changes in cellular calcium levels by interacting with various targets [9]. Numerous studies have been devoted to the understanding CaM mechanism of action. Early m

• In the cytoplasm the ternary CRM cargo

  2020-07-28

  

  In the cytoplasm, the ternary CRM1–cargo–RanGTP complex is disassembled by the action of Ran-binding proteins RanBP1/2 and RanGAP. A recent kinetic study showed that the Ran-binding domains (RanBDs) of the cytoplasmic proteins RanBP1 and RanBP2, but not RanGAP, accelerate dissociation of NES from CR

• Sex also influences COMT effects on cognition

  2020-07-28

  

  Sex also influences COMT effects on cognition. Women have 20%–30% less COMT activity than men (Chen et al., 2004, Fahndrich et al., 1980). Both Raz et al. (2011)O\'Hara et al. (2006) found that sex interacted with COMT genotype such that older men who had a Val allele showed greater negative effects

• Introduction We have recently identified that caseinkinase

  2020-07-28

  

  Introduction We have recently identified that caseinkinase 2 (CK2) inhibition protects white matter (WM) from ischemic injury. We focused our research on CK2 because upregulation of CK2 activity is associated with many diseases, including ischemic injury [1,[6], [7], [8]]. This review highlights a

• In this study CK C prepared from BL DE

  2020-07-28

  

  In this study, CK1δ(ΔC) prepared from BL21(DE3)pλPP had the highest kinase activity among the three isoforms tested when using casein as a substrate. Therefore, CK1δ(ΔC) from BL21(DE3)pλPP has the potential to be a “phosphorylating reagent” that may be widely used in experiments of phosphorylation a

• Our results signify that both membrane anchored and soluble

  2020-07-27

  

  Our results signify that both membrane-anchored and soluble isoforms of DDR ECD sirtuins may be important in ECM remodeling. In this regard, several soluble collagen-binding proteins secreted in the ECM—decorin,3, 32, 33, 34 lumincan,3, 34, 35 biglycan,34, 36 fibromodulin,34, 35, 36 periostin, aggre

• B Hits with contact footprints similar to the known

  2020-07-27

  

  (B) Hits with contact footprints similar to the known inhibitors or true active compounds have greater chances to turn into competitive inhibitors. So in pose-clustering, interaction profiles of docking poses were compared with six well known antifolates (PYR, CYC, WR99210, TMP, MTX, INH1 and INH2)

• DDR receptor effector mechanisms are not

  2020-07-27

  

  DDR receptor effector mechanisms are not well understood. Most descriptions of DDR function have focused on downstream signaling pathways activated by collagen that regulate cell proliferation and transcriptional activation [7]. Natural occurring or induced DDR2−/− genotypes in mice induce dwarfism,

• br Role of DDR receptor in the development of Bone

  2020-07-27

  

  Role of DDR2 receptor in the development of Bone in human DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix

• Collectively the results presented here provide new insights

  2020-07-27

  

  Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of

• br Materials and methods br

  2020-07-27

  

  Materials and methods Results Discussion Although no increase in DAPK activity was detected at early time points associated with neuronal apoptosis, it is possible that the spread of apoptosis through the hmg-coa reductase inhibitor following HI is not synchronized enough to yield a large,

• Because bronchoconstriction is one of the causes of air trap

  2020-07-27

  

  Because bronchoconstriction is one of the causes of air-trapping, we comparatively evaluated the effect of an adrenergic β2 NSC 87877 agonist on LTC4- and LTD4-induced asthmatic responses in guinea pigs. Inhaled LTC4-induced increase in sRaw and airway hyperinflation in S-hexyl GSH-treated guinea p

• Effect modification of CYP A genotype on the association

  2020-07-27

  

  Effect modification of CYP3A genotype on the association between prenatal exposure to MeHg and child neurodevelopment was evaluated. For CYP3A7, the overall coefficient of cord blood THg on MDI was positive (i.e. improving MDI score with increasing cord blood THg concentrations) and statistically si

• The central role of TNF in inflammation

  2020-07-27

  

  The central role of TNF-α in inflammation and the immune system is established (reviewed in Ref. [34]) where it regulates such cellular processes as cytokine induction, proliferation, differentiation, and apoptosis. In contrast to these roles, however, several studies have suggested a function for T

• Expression of CSF R is normally

  2020-07-27

  

  Expression of CSF-1R is normally restricted to monocytes/macrophages, osteoclasts, and a few non-hematopoietic cell types including epithelial intestinal HU 308 of the colon and certain subpopulations of neurons [36]. In addition, CSF-1R is transiently expressed during processes that require tissue

15781 records 781/1053 page Previous Next First page 上5页 781782783784785 下5页 Last page