• br Role of ferroptosis in

  2022-03-12

  

  Role of ferroptosis in PD Pathological progression of PD displays features that may facilitate ferroptosis induction such as elevated iron in the SNpc [49], [57], [88], [122], depleted GSH [194] and lipid peroxidation [51]. Iron chelation has been shown to mitigate the motor impairment in mouse m

• The membrane metalloendopeptidase MME gene is located at hum

  2022-03-12

  

  The membrane metalloendopeptidase (MME) gene is located at human chromosome 3q21-27. It encodes a 100-kD type II transmembrane glycoprotein, a widely expressed membrane metalloendopeptidase that degrades a number of substrates. The active site of the enzyme faces the extracellular space. MME is wid

• br Conclusion In conclusion our results demonstrate that

  2022-03-11

  

  Conclusion In conclusion, our results demonstrate that incubation of both LAD and SCA rat coronary arteries rapidly increases the ETB receptor-mediated contraction as well as upregulation of ETB receptor protein levels. These findings may have important experimental implications in tissue bath ex

• br Disp Cleavage and Membrane Trafficking

  2022-03-11

  

  Disp Cleavage and Membrane Trafficking Knowledge of how Disp is regulated in Shh-producing IC261 to control ligand deployment has, until recently, remained limited. Early studies examining Disp function in Madin–Darby Canine Kidney (MDCK) cells and Drosophila tissue suggested that it is likely to

• Recent work by Que et al with

  2022-03-11

  

  Recent work by Que et al with mouse models implicates GSNOR in the cause of asthma. GSNOR is expressed in multiple cell types in the lung, including airway epithelial cells and infiltrating leukocytes. After exposure to ovalbumin, GSNOR activity increased in airway lining fluid, perhaps reflecting i

• Previously we reported that the inhibition

  2022-03-11

  

  Previously, we reported that the inhibition of PKC-ζ and PKC-ε activity in hypertrophic adipocytes had deleterious effects on EPA-induced GPR120-mediated VEGF-A production [12]. However, the activation of PKC-θ, -ζ and -λ can also enhance the phosphorylation of IKK and p65, and facilitate the transl

• Phosphatase Inhibitor Cocktail 2 (100X in ddH2O) br Acknowle

  2022-03-11

  

  Acknowledgements This work was supported by Slovak Academy of Sciences grants VEGA 2/0052/10 and 2/0045/10. Both clinical observations and preclinical studies suggest that hypofunction of -methyl--aspartate (NMDA) receptor is implicated in the pathophysiology of schizophrenia. Thus, therapeuti

• The effects of these steroids namely the decrease in

  2022-03-11

  

  The effects of these steroids, namely the decrease in the peak and acceleration of desensitization could be observed in IGly activated by 100 μM glycine (concentration close to EC50). However, with an increase in glycine to 500 μM (a concentration close to saturating), the effect of steroids on the

• br Materials animals and methods br Results br

  2022-03-11

  

  Materials, animals and methods Results Discussion This study presents mice with a missense point mutation in R258 of FFAR1 that has functional consequences. Firstly, in islets of Ffar1R258W/R258W mice, both the physiological agonist palmitate and the synthetic agonist TUG-469 were unable to

• br Materials and methods br Results br

  2022-03-10

  

  Materials and methods Results Discussion Present study demonstrated the ability of a GIP agonist, D-Ala2GIP, to protect against the QA-induced neurobehavioral phenotype of HD in rats, for the first time. D-Ala2GIP treatment significantly improved the behavioral deficits, biochemical and neu

• Interestingly the subcellular localization of FBPase in hepa

  2022-03-10

  

  Interestingly, the subcellular localization of FBPase in hepatocytes and proximal tubule Idoxuridine reveals that FBPase is also able to translocate to the nucleus in these cell types. The nuclear localization of muscle-FBPase was recently reported [35]. This data corroborate our results on the abi

• Potential roles for S P in

  2022-03-10

  

  Potential roles for S1P in angiogenesis, cancer, and autoimmune diseases such as RA have been reported [73]. In RA synoviocytes, S1P has been shown to enhance expression of prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2) in response to the pro-inflammatory cytokines, TNF-α and interleukin (IL)-

• br STAR Methods br Acknowledgments

  2022-03-10

  

  STAR★Methods Acknowledgments Funding for this work was provided by grants from the US National Institute of Allergy and Infectious Diseases (NIAID) (R01-AI095068 and UM1-AI068613 to S.H.E. and U24-AI118633 to H.B.L.) and grant OPP1155863 from the Bill and Melinda Gates Foundation to S.J.E. Add

• Sulbactam Our extensive preliminary data suggest that the lo

  2022-03-10

  

  Our extensive preliminary data suggest that the loss of p300 (and resulting H3K27ac) is related to inorganic arsenic related diseases. Therefore, it may open a new avenue for alleviating the consequence of H3K27ac, for example, via boosting CBP enzymatic activity for at least partially compensating

• dhfr inhibitors A revolution in cancer immunotherapy has rec

  2022-03-10

  

  A revolution in cancer immunotherapy has recently emerged with the development of novel immunomodulatory antibodies, classified as immunostimulatory agonist monoclonal dhfr inhibitors (mAbs) or checkpoint blocking mAbs. CD40/CD40L, as an important costimulatory pathway, mediates a broad spectrum of

16529 records 496/1102 page Previous Next First page 上5页 496497498499500 下5页 Last page