We further show that Zfp iNSCs lines established from fetal

2018-10-20

We further show that Zfp521-iNSCs lines established from fetal, neonatal, and adult fibroblasts have the capacity to differentiate in vitro into the three main cell types: neurons, astrocytes and oligodendrocytes. This trilineage differentiation potential was also retained in three clonally derived

Given the significance of methylation demethylation during r

2018-10-20

Given the significance of methylation/demethylation during reprogramming, we set out to investigate the function of miR-29a in regulating the iPSC methylome. Although miR-29a was shown to directly regulate both de novo DNA methyltransferases and demethylases, we found that depletion of miR-29a resul

Removal of growth factor mediated

2018-10-20

Removal of growth factor-mediated self-renewal signaling in NPC cultures should result in increased expression of terminal differentiation markers (Graham et al., 2003; Sun et al., 2008). Indeed, in 2D monolayer cultures, ReNcell VM increased expression of proteins associated with terminal different

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2018-07-29