• The expression of T BRY

  2018-10-20

  

  The expression of T (BRY), taken as a marker of precursors of all mesodermal tissues, was here induced through the activation of the canonical Wnt signalling which has been identified as an inducer for the primitive streak. A novel GSK3β inhibitor compound, active at a lower concentration than that

• These findings predict that Lgr CBCs

  2018-10-20

  

  These findings predict that Lgr5-CBCs must have a significantly shorter lifespan than the reserve ISCs; otherwise, an age-related accumulation of Lgr5-CBCs would result from the constant generation of CBCs from the reserve ISCs. Indeed, this finite lifespan of Lgr5-CBCs can be observed in prior stud

• When compared with our previous studies Guhr et al

  2018-10-20

  

  When compared with our previous studies (Guhr et al., 2006; Löser et al., 2008, 2010, 2012), the current analysis revealed some relevant changes in the number and ranking of countries involved in hESC research. In addition, we substantiated that a country’s quantitative output of papers in hPSC rese

• channel modulator br Disclosure of potential conflicts of in

  2018-10-20

  

  Disclosure of potential conflicts of interest Acknowledgements Introduction In many cells, the plasma membrane and underlying channel modulator filaments interact dynamically with each other to produce cell surface blebs, which may be either dynamic (non-apoptotic) or apoptotic (Weng, 2016

• Since TGF levels and signaling are elevated in

  2018-10-20

  

  Since TGFβ levels and signaling are elevated in aged dystrophic muscle (Figure 1A), we next investigated whether endothelial and satellite transcription factor also undergo plastic fibrogenesis in vivo. To this end, we generated endothelial and satellite cell-lineage-tracing mice in two mdx dystrop

• Since TGF levels and signaling are elevated in

  2018-10-20

  

  Since TGFβ levels and signaling are elevated in aged dystrophic muscle (Figure 1A), we next investigated whether endothelial and satellite ionomycin also undergo plastic fibrogenesis in vivo. To this end, we generated endothelial and satellite cell-lineage-tracing mice in two mdx dystrophic backgro

• Several previous studies support the possibility that RPC

  2018-10-20

  

  Several previous studies support the possibility that RPC differentiation into podocytes may be involved in remission of different types of diseases, including proliferative glomerulonephritis (Rizzo et al., 2013), gestational pre-eclampsia (Penning et al., 2014), and diabetic nephropathy (Pichaiwon

• ikk inhibitor br Experimental Procedures br Author Contribut

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments We are deeply thankful to V. Fossati and N. Lamas for helpful critical reading of the manuscript and to J. Goldman for generously providing the O4 antibody. We thank J.-Y. Li for providing access to wild-type mice for deriving mES

• All PGCs differentiated from ESCs

  2018-10-20

  

  All PGCs differentiated from ESCs in our study, regardless of differentiation approach or sorting strategy, were capable of implementing ICC erasure at the Snprn ICC. However, unlike E9.5 PGCs from the embryo, the hypomethylated state at this ICC was unstable, and in every case re-methylation was in

• br Experimental Procedures br Author

  2018-10-20

  

  Experimental Procedures Author Contributions M.A. planned and performed the experiments and wrote the manuscript. T.N. helped in performing CTL redifferentiation experiments. S.Y. provided scientific discussion and technical support. T.Y. provided plasmids and helped in generating lentivirus v

• In the absence of SOX stem

  2018-10-20

  

  In the absence of SOX2+ stem cells and Notch signaling in Rbp-Jf/f, Prop1-Cre mutant mice, the pituitary glands are hypoplastic and dysmorphic. Interestingly, re-entry of PIT1+ lineages into the purchase Sepantronium after birth is delayed in the mutant. Consistent with our finding, reduced postnat

• br Results br Discussion Following transplantation into

  2018-10-20

  

  Results Discussion Following transplantation into immunodeficient mice, immature hESC-derived pancreatic progenitor p450 inhibitors develop over a lengthy maturation period into glucose-responsive, insulin secreting cells (Rezania et al., 2012; Bruin et al., 2013), although this process remai

• Although the FDA considers analogous cell product data

  2018-10-20

  

  Although the FDA considers analogous cell product data an acceptable option for preclinical studies, it requires substantial similarity between analogous animal and human products (FDA, 2013). Due to the significant differences in the innate and adaptive immune system (Mestas and Hughes, 2004), hema

• We further show that Zfp iNSCs lines established from fetal

  2018-10-20

  

  We further show that Zfp521-iNSCs lines established from fetal, neonatal, and adult fibroblasts have the capacity to differentiate in vitro into the three main cell types: neurons, astrocytes and oligodendrocytes. This trilineage differentiation potential was also retained in three clonally derived

• Given the significance of methylation demethylation during r

  2018-10-20

  

  Given the significance of methylation/demethylation during reprogramming, we set out to investigate the function of miR-29a in regulating the iPSC methylome. Although miR-29a was shown to directly regulate both de novo DNA methyltransferases and demethylases, we found that depletion of miR-29a resul

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